Few cosmeceuticals have impacted the aesthetic market like DefenAge® from Progenitor Biologics, LLC (Carlsbad, Calif.). This home-use topical is not only packed with compounds known to be beneficial to skin, it is free of compounds that, while appearing in many skincare formulations, are actually believed to be deleterious. Scientifically-proven Age-Repair Defensins® are the unique key active and basis for the ultimate success of this product.
“DefenAge has been very successful in my practice,” said Amy Forman Taub, M.D., a dermatologist and founder of Advanced Dermatology and Skinfo (Lincolnshire, Ill. and Glencoe, Ill., respectively). Dr. Taub is also a researcher and lead author on a landmark double-blind, multicenter DefenAge study1 investigating the mechanism of action of Age-Repair Defensins.
“The way it works has been proven in rigorous scientific study, and there’s really no group that I can think of that couldn’t use DefenAge, or wouldn’t benefit from its nourishing and refreshing qualities,” she continued. “Who doesn’t want fresher, healthier, younger looking skin?”
The DefenAge regimen includes three products (termed the Clinical Power Trio), which starts with 8-in-1 BioSerum and 24/7 Barrier Balance Cream for twice daily use, and 2-minute Reveal Masque for use once or twice a week. In addition to the variety of vitamins, antioxidants and other compounds which protect, nourish and moisturize the skin, the Age-Repair Defensins in the formulation have been scientifically demonstrated1 to activate LGR6+ master stem cells. These master stem cells are the antecedent for all skin cell lines and key actors in wound healing, which lie dormant.
“It is unique in that it helps clear away old, dead skin cells to make way for fresh, new, healthy skin cells,” Dr. Taub expressed. “Age-Repair Defensins stimulate inherent stem cells as part of the natural process of cell turnover.
“The critical difference with Age-Repair Defensins is that instead of simply stimulating processes in existing skin cells – which are older and already damaged, and thus not as effective at making skin look fresh – they work on progenitor cells that are just waiting to be activated,” Dr. Taub continued.
As many physicians are discovering, there is virtually no aesthetic treatment that can’t be theoretically enhanced in some way by DefenAge.
“We can use DefenAge with pretty much all of the treatments we provide, and often we have patients start using DefenAge two to four weeks before the first session of an in-office procedure, because improving skin quality improves the ability of the skin to respond to treatment, so we see better results whether we’re using lasers, skin tightening, microneedling or anything else. After treatment, DefenAge can maximize healing and recovery, as well as help maintain the results.”
A new addition to the product line is 1-step Multi-Cleanse, the first cleanser in the DefenAge family, featuring natural prebiotics to stabilize skin ecology. It is designed not only to hydrate the skin as it washes away dirt, oils and makeup, but to also complement the Clinical Power Trio by further stimulating the body’s naturally-present Defensins.
